Can mesoporous nanoparticles promote bioavailability of topical pharmaceutics?

When applied to skin, particulate matter has been shown accumulate in hair follicles. In addition follicles, the skin topography also incorporates trench-like furrows where particles potentially can accumulate; however, have not as thoroughly investigated a drug delivery perspective. Depending on body site, combined follicle orifices cover up 10% of surface, while easily 20%, reaching depths exceeding 25 µm. Hence, porous appropriate size and porosity could serve carriers for drugs be released follicles prior local or systemic absorption. this paper, we combine multiphoton microscopy, scanning electron Franz cell diffusion technology investigate ex-vivo accumulation mesoporous silica (average 400–600 nm, 2, 7 µm, respectively), potential which vehicles topical broad-spectrum antibiotic metronidazole. We detected smaller (400–600 nm) at about after rinsing, larger (7 µm) located more superficially skin. This implies that appropriately sized may valuable excipients optimizing bioavailability formulations. work highlights delivery.